Hydroxypropyl methylcellulose phthalate
Hydroxypropyl Methyl Cellulose Phthalate
CAS: 9050-31-1
Molecular Formula: C14H16N4
Hydroxypropyl methylcellulose phthalate - Names and Identifiers
Hydroxypropyl methylcellulose phthalate - Physico-chemical Properties
| Molecular Formula | C14H16N4 |
| Molar Mass | 240.30364 |
| Density | 0.6g/mLat 25°C(lit.) |
| Melting Point | >145°C (dec.)(lit.) |
| Boling Point | 456.7°C at 760 mmHg |
| Flash Point | 230°C |
| Solubility | H2O: Limited solubility at low pH, soluble at pH ≥4.2.soluble |
| Vapor Presure | 1.58E-08mmHg at 25°C |
| Appearance | neat |
| Refractive Index | 1.681 |
Hydroxypropyl methylcellulose phthalate - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 1 |
| RTECS | FJ5954000 |
| HS Code | 39129090 |
Hydroxypropyl methylcellulose phthalate - Standard
Authoritative Data Verified Data
This product is a monoester of Hypromellose and phthalic acid. Based on the dry product, the amount of phthaloyl group should be 21.0% to 35.0%.
Last Update：2024-01-02 23:10:35
Hydroxypropyl methylcellulose phthalate - Trait
Authoritative Data Verified Data
- This product is white or off-white powder or granules; Odorless, tasteless.
- This product is almost insoluble in water and anhydrous ethanol, and it is very slightly soluble in acetone and toluene. In methanol-acetone (1: 1), methanol-two gas methane (1: 1) dissolved in.
viscosity
take this product 10g,105T: dry for 1 hour, add methanol-dichloromethane (1 : l) ( g /g) mixture solution 90g to dissolve, in 20C ± 0.1X:, the viscosity shall be 0633 to 80% of the indicated viscosity when determined according to law (General rule 120% second method).
Last Update：2022-01-01 11:25:28
Hydroxypropyl methylcellulose phthalate - Differential diagnosis
Authoritative Data Verified Data
The infrared absorption spectrum of this product is consistent with that of the reference product (General rule 0402).
Last Update：2022-01-01 11:25:28
Hydroxypropyl methylcellulose phthalate - Exam
Authoritative Data Verified Data
chloride
take this product 0. l g, add 0.2m o l/L sodium hydroxide solution 40ml to dissolve, add 1 drop of phenolphthalein test solution, add dilute nitric acid Dropwise until the red color disappears, and add 5 m l of dilute nitric acid, heating to boiling to produce a colloidal precipitate, cooling, filtering, washing the precipitate several times with a small amount of distilled water, combining the filtrate, shaking, and placing in a 50ml Nessler cuvette as a test solution. Inspection according to law (General rule 0801), compared with the control solution made of standard gasification sodium solution 7. 0ml, should not be deeper (0. 07%).
free phthalic acid
take 0.2g of this product, accurately weigh, put it in a lOOml measuring flask, add about 50ml of acetonitrile, partially dissolve by ultrasound, then add 10ml of water, and completely dissolve by ultrasound, dilute with acetonitrile to the scale, shake well, as a test solution; Accurately weigh about lO m g of phthalic acid reference substance, put it in a 50ml measuring flask, add acetonitrile to dissolve and dilute to the scale, shake well, take 5ml accurately, put it in a 50ml measuring flask, add water 5 m K, dilute it to the scale with acetonitrile, shake well, and use it as a reference solution. Test according to high performance liquid chromatography (General 0512). Silica gel was bonded with eighteen alkyl silane as filler; Acetonitrile-0.1% trifluoroacetic acid (1 : 9) as mobile phase; Flow rate was 2.0 m l/m in; Detection wavelength was 235nm. 10ul of the reference solution was injected into the liquid chromatograph, and the relative standard deviation of the peak area should not be more than 1 .0% for S times of continuous injection. The sample solution and the reference solution were respectively injected with 10ul, and the chromatogram was recorded. If there is a chromatographic peak consistent with the retention time of phthalic acid in the chromatogram of the test solution, the peak area shall be calculated according to the external standard method, and the peak area shall not exceed 1 .0%.
moisture
take this product, according to the determination of moisture (General rule 0832 first method 1), the water content shall not exceed 5 .0%.
ignition residue
take l.O g of this product and check it according to law (General rule 0841>, the residue shall not exceed.
precious metals
The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).
arsenic salt
take this product 1.0G, add calcium hydroxide l .O g, mix, add water and stir evenly, after drying, first burn with small fire to charring, then burn at 600°C to Ash the whole, let it cool, add hydrochloric acid 5M l and water 23ml to dissolve, check according to law (General Principles 0822 The first law), should comply with the provisions (0,0002%).
Last Update：2022-01-01 11:25:29
Hydroxypropyl methylcellulose phthalate - Content determination
Authoritative Data Verified Data
take this product about l.O g, precision weighing, add 50m of mixed solution of ethanol-acetone-water (2:2:1) to dissolve, add 2 drops of phenolphthalein indicator solution, with sodium hydroxide titration solution (O .lm o l/L) titration, and the titration results were corrected with a blank test.
Last Update：2022-01-01 11:25:29
Hydroxypropyl methylcellulose phthalate - Category
Authoritative Data Verified Data
pharmaceutical excipients, coating materials.
Last Update：2022-01-01 11:25:29
Hydroxypropyl methylcellulose phthalate - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 11:25:30
Hydroxypropyl methylcellulose phthalate - Marking
Authoritative Data Verified Data
The viscosity is indicated in mPa.S or Pa. s.
Last Update：2022-01-01 11:25:30
Hydroxypropyl methylcellulose phthalate - Nature
melting point> 145°C (dec.)(lit.)
solubility H2O: Limited solubility at low pH, soluble at pH ≥ 4.2.soluble
CAS DataBase Reference 9050-31-1
EPA chemical substance information cellose, hydrogen 1,2-benzenedicarboxylate, 2-hydroxypropyl methyl ether(9050-31-1)
Last Update：2024-04-10 22:29:15
Hydroxypropyl methylcellulose phthalate - Safety Information
safety instructions 24/25
WGK Germany 1
RTECS# FJ5954000
Last Update：2024-04-10 22:29:15
Hydroxypropyl methylcellulose phthalate - Ecological Data
It is usually not harmful to water. If there is no government permission, do not discharge the material into the surrounding environment.
Last Update：2024-04-09 21:54:55
Hydroxypropyl methylcellulose phthalate - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | hydroxypropyl methyl cellulose phthalate is an enteric film coating material with excellent properties. |
Last Update：2024-04-09 21:01:54
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Product Name: 1-(2-methylpropyl)imidazo[4,5-c]quinolin-4-amine Visit Supplier Webpage Request for quotationCAS: 9050-31-1
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
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Multiple SpecificationsSpot supply
Product Name: Hydroxypropyl methylcellulose phthalate Request for quotationCAS: 9050-31-1
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
Spot supply
Product Name: Hydroxypropylmethylcellulosephthalate Request for quotationCAS: 9050-31-1
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: 1-(2-methylpropyl)imidazo[4,5-c]quinolin-4-amine Visit Supplier Webpage Request for quotationCAS: 9050-31-1
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
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Product Name: Hydroxypropyl Methylcellulose Phthalate Visit Supplier Webpage Request for quotationCAS: 9050-31-1
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View History
Hydroxypropyl methylcellulose phthalate
26575-93-9
34701-33-2
tris(pentafluorophenyl)phosphine
112006-75-4
11084-06-3
Samarium phosphate
26575-93-9
34701-33-2
tris(pentafluorophenyl)phosphine
112006-75-4
11084-06-3
Samarium phosphate